Study of antioxidant activity of selected monocarbohydrazone derivatives

Gorana Mrđan; Borko Matijević; Sanja Vlaisavljević; Đenđi Vaštag; Suzana Apostolov

doi:10.5937/zasmat2101005M

Autori

Gorana Mrđan University of Novi Sad, Faculty of Science, Department of Chemistry, Biochemistry and Environmental Protection, Serbia Autor
Borko Matijević University of Novi Sad, Faculty of Science, Department of Chemistry, Biochemistry and Environmental Protection, Serbia Autor
Sanja Vlaisavljević University of Novi Sad, Faculty of Science, Department of Chemistry, Biochemistry and Environmental Protection, Serbia Autor
Đenđi Vaštag University of Novi Sad, Faculty of Science, Department of Chemistry, Biochemistry and Environmental Protection, Serbia Autor
Suzana Apostolov University of Novi Sad, Faculty of Science, Department of Chemistry, Biochemistry and Environmental Protection, Serbia Autor

DOI:

https://doi.org/10.5937/zasmat2101005M

Ključne reči:

antioksidant, ABTS, biološka aktivnost, DPPH, FRAP, monokarbohidrazoni

Apstrakt

Mnogi derivati karbohidrazona pokazali su širok spektar bioloških aktivnosti. U prethodnim studijama ova jedinjenja su se pokazala kao odlični antikancerogeni, antitumorski, antibakterijski, antimikrobni i antioksidantni agensi. Monokarbohidrazoni, kao jedni od derivata karbohidrazona, su do sada malo istraženi. Iz tog razloga, u ovoj studiji, osam novosintetisanih monokarbohidrazona podvrgnuto je ispitivanju njihove antioksidativne aktivnosti primenom različitih testova. Da bi se utvrdila efikasnost monokarbohidrazona kao potencijalnih agenasa za uklanjanje radikala, korišćeni su DPPH, ABTS i FRAP testovi. Dobijeni rezultati predstavljaju osnovu za dalja ispitivanja ovih jedinjenja kao biološki aktivnih supstanci.

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