Analiza biomedicinskih materijala i delova - napredna nano(mikro)-karakterizacija tehnikama neutronskog snopa

Autori

  • Massimo Rogante Rogante Engineering Office, Civitanova Marche, Italy Autor

DOI:

https://doi.org/10.5937/zasmat2202146R

Ključne reči:

biomaterijali, biomedicinski uređaji, tehnike neutronskog snopa, nanostruktura, mikrostruktura

Apstrakt

Napredak u proučavanju biomedicinskih materijala i uređaja, posebno zavisi od primene efikasnih tehnika karakterizacije za procenu ključnih fizičkih parametara vezanih za performanse, oštećenja i kvalitet. Glavni cilj je uspostavljanje tačnih odnosa između makroskopskih funkcionalnih svojstava i nano(mikro) karakteristika. Brojni invazivni biomedicinski uređaji, na primer, planirani da ostanu u ljudskom telu tokom celog života pacijenta, jednom implantirani, deluju u jonskom okruženju krvi i u kontaktu su sa oslobođenim supstancama i ćelijama. Posledični efekti se moraju dodati ostalim faktorima starenja: dinamički stres pulsiranja je jedan od ovih efekata i tiče se rada samoproširujućih stentova instaliranih u arterijama, kao što je karotida, da bi se ispravila stenoza. Tehnike neutronskog snopa su odlično sredstvo za proučavanje materijala i delova od biomedicinskog interesa, doprinoseći rešavanju važnih pitanja povezanih sa metodološkim ograničenjima opšte prihvaćenih metoda analize: njihovi rezultati, komplementarno, mogu pomoći u poboljšanju kvaliteta i funkcionalnosti. Ovaj rad se bavi naprednom nano(mikro)-karakterizacijom biomedicinskih materijala i delova ovim nedestruktivnim i neinvazivnim nuklearnim metodama. Pominju se i neki primeri koji se odnose na biološko polje. Za primenu u biomedicinskom i industrijskom sektoru, Inženjerska kancelarija Rogante je razvila posebne metodološke pristupe i namenske postupke obrade i tretmana.

Reference

Cambiaghi, T., Spertino, A., Bertoglio, L., Chiesa, R. (2017) Fracture of a Supera Interwoven Nitinol Stent After Treatment of Popliteal Artery Stenosis.Journal of Endovascular Therapy, 24(3): 447-449

https://doi.org/10.1177/1526602817698655

Combet, S. (2020) An Introduction to Neutrons for Biology.EPJ Web of Conferences, 236(01001): 18-18

https://doi.org/10.1051/epjconf/202023601001

di Cola, E., Cantu', L., Brocca, P., Rondelli, V., Fadda, G.C., Canelli, E., Martelli, P., Clementino, A., Sonvico, F., Bettini, R., Del, F.E. (2019) Novel O/W Nanoemulsions for Nasal Administration: Structural Hints in the Selection of Performing Vehicles with Enhanced Mucopenetration.Colloids and Surfaces B: Biointerfaces, 183: 110439

https://doi.org/10.1016/j.colsurfb.2019.110439

Feigin, L.A., Svergun, D.I. (1987) Structure Analysis by Small-Angle X-Ray and Neutron Scattering. Boston: Springer

https://doi.org/10.1007/978-1-4757-6624-0

Fukuda, Y., Hirano, Y., Kusaka, K., Inoue, T., Tamada, T. (2020) High-Resolution Neutron Crystallography Visualizes an OH-Bound Resting State of a Copper-Containing Nitrite Reductase.PNAS, 117(8): 4071-4077

https://doi.org/10.1073/pnas.1918125117

Garriboli, L., Jannello, A.M. (2013) Fracture of a Popliteal Nitinol Stent: Case Report and Review of the Literature.EJVES Extra, 25(3): e15-e17

https://doi.org/10.1016/j.ejvsextra.2012.10.003

https://doi.org/10.1016/j.ejvs.2012.10.020

Gatto, A., Rogante, M., Santecchia, E., Mengucci, P. (2019) in: MTSM 2019, Split, Croatia, proceedings, 41-47

Gerelli, Y. (2020) Applications of Neutron Reflectometry in Biology.EPJ Web of Conferences, 236: 04002, 18-18

https://doi.org/10.1051/epjconf/202023604002

Glatter, O., Kratky, O. (1982) Small Angle X-ray Scattering. New York: Academic Press

Jeffries, C.M., Pietras, Z., Svergun, D.I. (2020) The Basics of Small-Angle Neutron Scattering: SANS for New Users of Structural Biology.EPJ Web of Conferences, 236: 03001, 35-35

https://doi.org/10.1051/epjconf/202023603001

Luchini, A., Micciulla, S., Corucci, G., Batchu, K.C., Santamaria, A., Laux, V., Darwish, T., Russell, R.A., Thepaut, M., Bally, I., Fieschi, F., Fragneto, G. (2021) Lipid Bilayer Degradation Induced by SARS-CoV-2 Spike Protein as Revealed by Neutron Reflectometry.Scientific Reports, 11(1): 14867

https://doi.org/10.1038/s41598-021-93996-x

https://doi.org/10.21203/rs.3.rs-531349/v1

Mahieu, E., Ibrahim, Z., Moulin, M., Härtlein, M., Franzetti, B., Martel, A., Gabel, F. (2020) The Power of SANS, Combined with Deuteration and Contrast Variation, for Structural Studies of Functional and Dynamic Biomacromolecular Systems in Solution.EPJ Web of Conferences, 236: 03002, 10-10

https://doi.org/10.1051/epjconf/202023603002

Morgan, N.B. (2004) Medical Shape Memory Alloy Applications: The Market and Its Products.Materials Science and Engineering A, 378(1-2): 16-23

https://doi.org/10.1016/j.msea.2003.10.326

Perissinotto, F., Rondelli, V., Senigagliesi, B., Brocca, P., Almásy, L., Bottyán, L., Merkel, D.G., Amenitsch, H., Sartori, B., Pachler, K., Mayr, M., Gimona, M., Rohde, E., Casalis, L., Parisse, P. (2021) Structural Insights into Fusion Mechanisms of Small Extracellular Vesicles with Model Plasma Membranes.Nanoscale, 13(10): 5224-5233

https://doi.org/10.1039/D0NR09075A

Qian, S., Sharma, V.K., Clifton, L.A. (2020) Understanding the Structure and Dynamics of Complex Biomembrane Interactions by Neutron Scattering Techniques.Langmuir, 36(50): 15189-15211

https://doi.org/10.1021/acs.langmuir.0c02516

Reddy, A.V., Alwair, H., Trewby, P.N. (2003) Fractured Esophageal Nitinol Stent: Report of Two Fractures in the Same Patient.Gastrointestinal Endoscopy, 57(1): 138-139

https://doi.org/10.1067/mge.2003.35

Rogante, M., Rosta, L. (2017) Neutrons for Health. Bad Reichenhall, Germany, abstract booklet, 25-25

Rogante, M. (2021) Structural Materials. Bratislava, Slovakia, 13-13, book of abstracts

Rogante, M. (2008) in: 1st Italian Workshop for Industry 'Industrial Applications of Neutron Techniques', Civitanova Marche, Italy, 40-120

Rogante, M. (2016) Caratterizzazione Avanzata Di Dispositivi Medici Invasivi Mediante Tecniche Neutroniche.Tecnica Ospedaliera, 3: 58-65

Rogante, M., Lebedev, V.T., Radulescu, A. (2018) in: MTSM 2018, Split, Croatia, proceedings, Split, 159-166

Rogante, M., Lebedev, V.T., Rogante, L., Brunello, G., Rustichelli, F., Zavan, B. (2021) SARS-CoV-2 and Other Coronaviruses: Innovative Approaches of Advanced Characterization Based on Large Machines of Physics.Journal of Characterization, 1(3): 137-147

https://doi.org/10.29228/JCHAR.52780

Rogante, M., Lebedev, V.T. (2007) Nanostructure Characterisation by SANS for Investigation on Ageing, Book Ageing EUR 22887 EN. Luxembourg: Office for Official Publications of the European Communities, 67-78

Rogante, M., Buhagiar, J., Cassar, G., Debono, M., Lebedev, V., Mikula, P., Ryukhtin, V. (2019) Neutron Investigation of Nitinol Stents and Massive Samples Before and After PIRAC Coating.Procedia Structural Integrity, 23: 95-100

https://doi.org/10.1016/j.prostr.2020.01.069

Rogante, M., Pasquini, U., Bonetti, M.G. (2011) Applying Neutron Techniques to the Analysis of Nitinol Stents.European Medical Device Technology, 2(9): 34-41

Rogante, M., Pasquini, U., Rosta, L., Lebedev, V. (2011) Feasibility Study for the Investigation of Nitinol Self-Expanding Stents by Neutron Techniques.Physica B: Condensed Matter, 406(3): 527-532

https://doi.org/10.1016/j.physb.2010.11.028

Rogante, M., Lebedev, V.T. (2007) Microstructural Characterization of Polymeric Materials by Small Angle Neutron Scattering.Polymer Engineering & Science, 47(8): 1213-1219

https://doi.org/10.1002/pen.20760

Santillo, M. (2008) Fracture and Crack Propagation Study of a Superficial Femoral Artery Nitinol Stent. Pavia: University of Pavia, Thesis

Williams, C., May, R.P., Guinier, A. (1994) Characterisation of Materials, Book Materials Science and Technology. Weinheim: VCH Verlagsgesellschaft, 611-656

Zaccai, N.R., Coquelle, N. (2020) Opportunities and Challenges in Neutron Crystallography.EPJ Web of Conferences, 236: 02001, 22-22

https://doi.org/10.1051/epjconf/202023602001

##submission.downloads##

Objavljeno

2022-06-15

Broj časopisa

Rubrika

Articles