Study of antioxidant activity of selected monocarbohydrazone derivatives

Gorana Mrđan; Borko Matijević; Sanja Vlaisavljević; Đenđi Vaštag; Suzana Apostolov

doi:10.5937/zasmat2101005M

Authors

Gorana Mrđan University of Novi Sad, Faculty of Science, Department of Chemistry, Biochemistry and Environmental Protection, Serbia Author
Borko Matijević University of Novi Sad, Faculty of Science, Department of Chemistry, Biochemistry and Environmental Protection, Serbia Author
Sanja Vlaisavljević University of Novi Sad, Faculty of Science, Department of Chemistry, Biochemistry and Environmental Protection, Serbia Author
Đenđi Vaštag University of Novi Sad, Faculty of Science, Department of Chemistry, Biochemistry and Environmental Protection, Serbia Author
Suzana Apostolov University of Novi Sad, Faculty of Science, Department of Chemistry, Biochemistry and Environmental Protection, Serbia Author

DOI:

https://doi.org/10.5937/zasmat2101005M

Keywords:

antioxidant, ABTS, biological activity, DPPH, FRAP, monocarbohydrazones

Abstract

Many of carbohydrazone derivatives have shown a wide range of biological activities. In previous studies, these compounds have proven to be excellent anti-cancer, antitumor, antibacterial, antimicrobial and antioxidant agents. Monocarbohydrazones, as one of the carbohydrazone derivatives, have been slightly explored. Due to that reason, in this study, eight newly synthesized monocarbohydrazones were subjected to examinations by the use of three antioxidant tests. To determine the effectiveness of monocarbohydrazone as potential radical scavengers, DPPH (2,2-Diphenyl-1-picrylhydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) and FRAP (Ferric Reducing Antioxidant Power) assays were used. The obtained results could open the door for further studies of these compounds as biologically active substances.

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